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Biomedical project Skulachev ions
 
Biomedical project Skulachev ions
 








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Publications

Basic mechanism and the concept

Mechanism of coupling of oxidative phosphorylation and the membrane potential of mitochondria.
Liberman EA, Topaly VP, Tsofina LM, Jasaitis AA, Skulachev VP. (1969), Nature, 222:1076-8
http://www.ncbi.nlm.nih.gov/pubmed/?term=5787094
PMID: 5787094

Programmed death phenomena: from organelle to organism.
Skulachev VP. (2002), Ann N Y Acad Sci. 959:214-37.
http://www.ncbi.nlm.nih.gov/pubmed/?term=11976198
PMID:11976198
 
Programmed and altruistic ageing.
Valter D. Longo, Joshua Mitteldorf and Vladimir P. Skulachev.  (2005) Nature Reviews Genetics. 6: , 866-872
http://www.ncbi.nlm.nih.gov/pubmed/?term=16304601
PMID: 16304601

How to Clean the Dirtiest Place in the Cell: Cationic Antioxidants as Intramitochondrial ROS Scavengers
Skulachev VP. (2005), IUBMB Life, 57: 305 – 310
http://www.ncbi.nlm.nih.gov/pubmed/16036614
PMID: 16036614

Aging as a mitochondria-mediated atavistic program: can aging be switched off?
Skulachev VP, Longo VD.
Ann N Y Acad Sci. 2005 Dec;1057:145-64.
http://www.ncbi.nlm.nih.gov/pubmed/?term=16399892
PMID:16399892

Aging as a particular case of phenoptosis, the programmed death of an organism (a response to Kirkwood and Melov "On the programmed/non-programmed nature of ageing within the life history").
Skulachev VP.(2011), Aging (Albany NY). 3:1120-3.
http://www.ncbi.nlm.nih.gov/pubmed/?term=22146104
PMID: 22146104

What is "phenoptosis" and how to fight it?
Skulachev VP.
Biochemistry (Mosc). 2012 Jul;77(7):689-706. doi: 10.1134/S0006297912070012. Review.
http://www.ncbi.nlm.nih.gov/pubmed/?term=22817532
PMID:22817532

Project results reviews:

An attempt to prevent senescence: A mitochondrial approach
Skulachev V.P. et al, (2009), Biochim. Biophys. Acta, 1787:437-61
http://www.ncbi.nlm.nih.gov/pubmed/19159610
PMID: 19159610

Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies.
Skulachev et al. (2011), Current drug targets, 12:800-26
http://www.ncbi.nlm.nih.gov/pubmed/21269268
PMID: 21269268

SkQ1 treatment and food restriction--two ways to retard an aging program of organisms.
Skulachev VP.
Aging (Albany NY). 2011 Nov;3(11):1045-50.
http://www.ncbi.nlm.nih.gov/pubmed/22170754
PMID: 22170754

Cationic antioxidants as a powerful tool against mitochondrial oxidative stress.
Skulachev VP. (2013) Biochem Biophys Res Commun. 441(2):275-9.
http://www.ncbi.nlm.nih.gov/pubmed/24161394
PMID: 24161394

Mitochondria-targeted antioxidants and metabolic modulators as pharmacological
interventions to slow ageing.
Gruber et al (2013) Biotechnol Adv. 31:563-92
http://www.ncbi.nlm.nih.gov/pubmed/?term=23022622
PMID: 23022622

Experimental papers: first disclosure

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: synthesis and in vitro studies.
Antonenko YN et al. (2008), Biochemistry (Mosc), 73:1273-87.
http://www.ncbi.nlm.nih.gov/pubmed/19120014
PMID: 19120014

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke).
Bakeeva et al. (2008), Biochemistry (Mosc), 73:1288-99.
http://www.ncbi.nlm.nih.gov/pubmed/19120015
PMID: 19120015

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells.
Agapova et al. (2008), Biochemistry (Mosc), 73:1300-16
http://www.ncbi.nlm.nih.gov/pubmed/19120016
PMID: 19120016

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals.
Neroev et al. (2008), Biochemistry (Mosc), 73:1317-28.
http://www.ncbi.nlm.nih.gov/pubmed/19120017
PMID: 19120017

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence.
Anisimov et al. (2008), Biochemistry (Mosc), 73:1329-42
http://www.ncbi.nlm.nih.gov/pubmed/19120018
PMID: 19120018

Experimental papers: mechanism

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: synthesis and in vitro studies.
Antonenko YN et al. (2008), Biochemistry (Mosc), 73:1273-87.
http://www.ncbi.nlm.nih.gov/pubmed/19120014
PMID: 19120014

Kinetic analysis of permeation of mitochondria-targeted antioxidants across bilayer lipid membranes.
Rokitskaya et al. (2008), J. Membr. Biol. 224:9-19.
http://www.ncbi.nlm.nih.gov/pubmed/18807085
PMID: 18807085
Chain-breaking antioxidant activity of reduced forms of mitochondria-targeted quinones, a novel type of geroprotectors.
Roginsky et al. (2009), Aging (Albany NY). 1:481-9
PMID: 20195487

Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore.
Severin et al. (2010), Proc. Natl. Acad.Sci. U S A., 107:663-8.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20080732
PMID: 20080732

Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs).
Skulachev et al. (2010), Biochim. Biophys. Acta, 1797:878-89.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20307489
PMID: 20307489

Mitochondria as source of reactive oxygen species under oxidative stress. Study with novel mitochondria-targeted antioxidants--the "Skulachev-ion" derivatives.
Izyumov et al. (2010), Biochemistry (Mosc). 75:123-9.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20367598
PMID: 20367598

Mitochondria-targeted penetrating cations as carriers of hydrophobic anions through lipid membranes.
Rokitskaya et al. (2010),Biochim. Biophys. Acta, 1798:1698-706
http://www.ncbi.nlm.nih.gov/pubmed/?term=20510172
PMID: 20510172

Derivatives of rhodamine 19 as mild mitochondria-targeted cationic uncouplers.
Antonenko et al. (2011), J. Biol. Chem., 286:17831-40.
http://www.ncbi.nlm.nih.gov/pubmed/?term=21454507
PMID: 21454507

Effect of liposomes on energy-dependent uptake of the antioxidant SkQR1 by isolated mitochondria.
Antonenko et al (2012), J Bioenerg. Biomembr., 44:453-60
http://www.ncbi.nlm.nih.gov/pubmed/?term=22723179
PMID: 22723179

Substitution of ether linkage for ester bond in phospholipids increases permeability of bilayer lipid membrane for SkQ1-type penetrating cations.
Il’yasova et al (2012), Biochemistry (Mosc), 77:1038-43
http://www.ncbi.nlm.nih.gov/pubmed/?term=23157264
PMID: 23157264

Superoxide scavenging activity of plastoquinone derivative
10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1).
Chistyakov et al (2012), Biochemistry (Mosc). 77:776-8
http://www.ncbi.nlm.nih.gov/pubmed/?term=22817541
PMID: 22817541

The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1
activity.
Labbé et al (2012) Exp Cell Res. 318:1620-32.
http://www.ncbi.nlm.nih.gov/pubmed/?term=22659133
PMID: 22659133

Role of charge screening and delocalization for lipophilic cation permeability of
model and mitochondrial membranes.
Trendeleva et al (2013), Mitochondrion. 13:500-6.
http://www.ncbi.nlm.nih.gov/pubmed/?term=23085197
PMID: 23085197

Electrogenic proton transport across lipid bilayer membranes mediated by cationic derivatives of rhodamine 19: comparison with anionic protonophores.
Rokitskaya at al., (2013), Eur Biophys J. 42(6):477-85.
http://www.ncbi.nlm.nih.gov/pubmed/?term=23558512
PMID: 23558512

Derivatives of the cationic plant alkaloids berberine and palmatine amplify
protonophorous activity of fatty acids in model membranes and mitochondria.
Pustovidko et al (2013), Mitochondrion. 13:520-5
http://www.ncbi.nlm.nih.gov/pubmed/?term=23026390
PMID: 23026390

Penetrating cations enhance uncoupling activity of anionic protonophores inmitochondria.
Antonenko et al, (2013), PLoS One, 8(4) : e61902
http://www.ncbi.nlm.nih.gov/pubmed/?term=23626747
PMID: 23626747

Experimental papers: new SkQ design

Novel mitochondria-targeted compounds composed of natural constituents: conjugates of plant alkaloids berberine and palmatine with plastoquinone.
Chernyak et al., (2012), Biochemistry (Mosc).77:983-95.
http://www.ncbi.nlm.nih.gov/pubmed/?term=23157257
PMID: 23157257

Novel penetrating cations for targeting mitochondria.
Chernyak et al, (2013) Curr Pharm Des. 19:2795-806
http://www.ncbi.nlm.nih.gov/pubmed/?term=23092317
PMID: 23092317

SkBQ - prooxidant addressed to mitochondria.
Vyssokikh et al (2013), Biochemistry (Mosc).78:1366-70.
http://www.ncbi.nlm.nih.gov/pubmed/?term=24460971
PMID: 24460971

In search of novel highly active mitochondria-targeted antioxidants: thymoquinone and its cationic derivatives.
Severina et al, (2013), FEBS Lett. 587:2018-24.
http://www.ncbi.nlm.nih.gov/pubmed/?term=In+search+of+novel+highly+active+mitochondria-targeted+antioxidants%3A+thymoquinone+and+its+cationic+derivatives
PMID: 23665033

Experimental papers: immunology and inflammation

Novel mitochondria-targeted antioxidants, "Skulachev-ion" derivatives, accelerate dermal wound healing in animals.
Demianenko et al., (2010), Biochemistry (Mosc).75:274-80.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20370605
PMID: 20370605

New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties.
Plotnikov et al., (2010) Biochemistry (Mosc). 75:145-50.
http://www.ncbi.nlm.nih.gov/pubmed/?term=New-generation+Skulachev+ions+exhibiting+nephroprotective+and+neuroprotective+properties
PMID: 20367601

Effect of plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) on contents of steroid hormones and NO level in rats.
Chistyakov et al., (2010), Biochemistry (Mosc). 75:1383-7.
http://www.ncbi.nlm.nih.gov/pubmed/?term=21314606
PMID: 21314606

In vivo immunoregulatory properties of the novel mitochondria-targeted
antioxidant SkQ1.
Yang  et al., (2012), Mol Immunol.52:19-29
http://www.ncbi.nlm.nih.gov/pubmed/?term=22591624
PMID: 22591624

Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection.
Plotnikov et al. (2013), Proc Natl Acad Sci U S A. 110:E3100-8
http://www.ncbi.nlm.nih.gov/pubmed/?term=23898194
PMID: 23898194

Experimental papers: Neurodegeneration models

Behavioral effects induced by mitochondria-targeted antioxidant SkQ1 in Wistar and senescence-accelerated OXYS rats.
Stefanova et al., (2010), J Alzheimers Dis. ;21:479-91.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20555140
PMID: 20555140

Mitochondria-targeted antioxidants as promising drugs for treatment of
age-related brain diseases.
Skulachev VP. (2012), J Alzheimers Dis.28:283-9.
http://www.ncbi.nlm.nih.gov/pubmed/?term=21987592
PMID: 21987592

Mitochondria-targeted plastoquinone antioxidant SkQ1 prevents amyloid-β-induced
impairment of long-term potentiation in rat hippocampal slices.
Kapay et al (2013), J Alzheimers Dis. 36:377-83.
http://www.ncbi.nlm.nih.gov/pubmed/?term=23735258
PMID: 23735258

Brain aging and mitochondria-targeted plastoquinone antioxidants of SkQ-type.
Isaev et al., (2013) Biochemistry (Mosc).78:295-300
http://www.ncbi.nlm.nih.gov/pubmed/?term=23586724
PMID: 23586724

Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1.
Stefanova et al., (2014), J Alzheimers Dis. 38:681-94.
http://www.ncbi.nlm.nih.gov/pubmed/?term=24047616
PMID: 24047616

Experimental papers: eye diseases models
Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals.
Neroev et al. (2008), Biochemistry (Mosc), 73:1317-28.
http://www.ncbi.nlm.nih.gov/pubmed/19120017
PMID: 19120017

Therapeutic action of the mitochondria-targeted antioxidant SkQ1 on retinopathy in OXYS rats linked with improvement of VEGF and PEDF gene expression.
Markovets et al., (2011), PLoS One. 6:e21682.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Therapeutic+action+of+the+mitochondria-targeted+antioxidant+SkQ1+on+retinopathy+in+OXYS+rats+linked+with+improvement+of+VEGF+and+PEDF+gene+expression
PMID: 21750722

SkQ1 slows development of age-dependent destructive processes in retina and
vascular layer of eyes of wistar and OXYS rats.
Saprunova et al (2012), Biochemistry (Mosc), 77:648-58
http://www.ncbi.nlm.nih.gov/pubmed/?term=22817465
PMID: 22817465

Experimental papers: protection from ischemia-related damage

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke).
Bakeeva et al. (2008), Biochemistry (Mosc), 73:1288-99.
http://www.ncbi.nlm.nih.gov/pubmed/19120015
PMID: 19120015


Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia/reperfusion.
Plotnikov et al., (2011) Biochim Biophys Acta. 1812:77-86.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20884348
PMID: 20884348

Mitochondria-targeted plastoquinone derivative SkQ(1) decreases ischemia-reperfusion injury during liver hypothermic storage for transplantation.
Cherkashina et al., (2011) Biochemistry (Mosc).76:1022-9.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Mitochondria-targeted+plastoquinone+derivative+SkQ(1)+decreases+ischemia-reperfusion+injury+during+liver+hypothermic+storage+for+transplantation
PMID: 22082271

The mitochondria-targeted antioxidants and remote kidney preconditioning ameliorate brain damage through kidney-to-brain cross-talk.
Silachev et al., (2012), PLoS One. 7:e51553.
http://www.ncbi.nlm.nih.gov/pubmed/?term=23272118
PMID: 23272118

Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention.
Kirpatovsky et al., (2013) Biochemistry (Mosc). 78:542-8.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Role+of+oxidative+stress+and+mitochondria+in+onset+of+urinary+bladder+dysfunction+under+acute+urine+retention
PMID: 23848157

Experimental papers: protection from other drugs side effects

Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss.
Jankauskas et al.,(2012), Biochemistry (Mosc). 77:666-70.
http://www.ncbi.nlm.nih.gov/pubmed/?term=22817467
PMID: 22817467

Experimental papers: general effect on aging

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence.
Anisimov et al. (2008), Biochemistry (Mosc), 73:1329-42
http://www.ncbi.nlm.nih.gov/pubmed/19120018
PMID: 19120018

Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats.
Obukhova et al., (2009), Aging (Albany NY),1:389-401.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20195490
PMID: 20195490

Effects of the mitochondria-targeted antioxidant SkQ1 on sexually motivated behavior in male rats.
Amstislavskaya et al., (2010) Pharmacol Biochem Behav. 96:211-6.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20470816
PMID: 20470816

Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents.
Anisimov et al., (2011), Aging (Albany NY). 3:1110-9.
http://www.ncbi.nlm.nih.gov/pubmed/22166671
PMID: 22166671

Effect of plastoquinone derivative 10-(6'-plastoquinonyl)
decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in
rats.
Chistyakov et al (2012), Biochemistry (Mosc). 77:1382-6.
http://www.ncbi.nlm.nih.gov/pubmed/?term=23244734
PMID: 23244734

Reactive oxygen species produced in mitochondria are involved in age-dependent changes of hematopoietic and mesenchymal progenitor cells in mice. A study with the novel mitochondria-targeted antioxidant SkQ1.
Shipounova et al., (2010), Mech Ageing Dev. 131:415-21.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20600239
PMID: 20600239

The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats.
Kolosova et al., (2012) Aging (Albany NY). 4:686-94.
http://www.ncbi.nlm.nih.gov/pubmed/?term=23104863
PMID: 23104863

Reproducible effects of the mitochondria-targeted plastoquinone derivative SkQ1 on Drosophila melanogaster lifespan under different experimental scenarios.
Krementsova et al (2012), Biogerontology. 13:595-607
http://www.ncbi.nlm.nih.gov/pubmed/?term=Reproducible+effects+of+the+mitochondria-targeted+plastoquinone+derivative+SkQ1+on+Drosophila+melanogaster+lifespan+under+different+experimental+scenarios
PMID: 23073710

Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure.
Vays et al., (2014), Aging (Albany NY).6:140-8.
http://www.ncbi.nlm.nih.gov/pubmed/?term=24519884
PMID: 24519884

Experimental papers: general effect on cancer

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells.
Agapova et al. (2008), Biochemistry (Mosc), 73:1300-16
http://www.ncbi.nlm.nih.gov/pubmed/19120016
PMID: 19120016

Mitochondria-targeted antioxidant SkQR1 selectively protects MDR (Pgp 170)-negative cells against oxidative stress
Fetisova et al. (2010), FEBS Letters, 584:562-6
http://www.ncbi.nlm.nih.gov/pubmed/19995561
PMID: 19995561

[Effect of plastoquinone derivative SkQ1 on benzo(a)pyrene-induced soft tissue carcinogenesis].
[Article in Russian]
Anikin IV et al (2013) Voprosy Onkologii;59(1):89-93
http://www.ncbi.nlm.nih.gov/pubmed/?term=%5BEffect+of+plastoquinone+derivative+SkQ1+on+benzo(a)pyrene-induced+soft+tissue+carcinogenesis
PMID: 23814832




 
 
 
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