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Aging (Albany NY).

Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats.

Obukhova LA, Skulachev VP, Kolosova NG.

Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk 630090, Russia.

Abstract

One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phosphonium (SkQ1). Here we report that, at low doses, SkQ1 (250 nmol/kg per day) inhibited age-dependent involution of the thymus in normal (Wistar) and senescence-prone (OXYS) rats. SkQ1 preserved total weight and volume of the organ, the volume of thymic cortex and medulla, the thymic cellularity, and the number of CD3+, CD4+, and CD8+ cells in the thymus. Moreover, SkQ1 was especially effective in senescence-prone rats. Thus SkQ1 slows down age-linked decline of the immune system, explaining prevention by this compound of infection-caused death in rodents, previously described in our group.

PMID: 20195490 [PubMed - indexed for MEDLINE]PMCID: PMC2830050
Ссылка: http://www.ncbi.nlm.nih.gov/pubmed/20195490

Aging (Albany NY). 2009 Apr 22;1(4):389-401.




 


 
 
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